Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection.

@article{Cross2011DimethylFA,
  title={Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection.},
  author={Stephanie A. Cross and Denise R. Cook and Anthony Wei-Shine Chi and Patricia J. Vance and Lorraine L. Kolson and Bethany J. Wong and Kelly L Jordan-Sciutto and Dennis L Kolson},
  journal={Journal of immunology},
  year={2011},
  volume={187 10},
  pages={
          5015-25
        }
}
Despite antiretroviral therapy (ART), HIV infection promotes cognitive dysfunction and neurodegeneration through persistent inflammation and neurotoxin release from infected and/or activated macrophages/microglia. Furthermore, inflammation and immune activation within both the CNS and periphery correlate with disease progression and morbidity in ART-treated individuals. Accordingly, drugs targeting these pathological processes in the CNS and systemic compartments are needed for effective… CONTINUE READING
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