Dimethyl Fumarate: Heterogeneous Catalysis for the Development of an Innovative Flow Synthesis

  title={Dimethyl Fumarate: Heterogeneous Catalysis for the Development of an Innovative Flow Synthesis},
  author={Fabia C Dede and Oreste Piccolo and Daniele Vigo},
  journal={Organic Process Research \& Development},
The present work describes the development of an improved synthesis of the active pharmaceutical ingredient (API) dimethyl fumarate. The use of continuous flow technology and the newly developed me... 
3 Citations


A Simple, Efficient, Green, Cost Effective and Chemoselective Process for the Esterification of Carboxylic Acids
Carboxylic acids have been esterified under mild and solvent-free conditions in high yield and purity using the green reagents, dimethyl carbonate and diethyl carbonate, under acid catalysis. The
Continuous-flow synthesis of dimethyl fumarate: a powerful small molecule for the treatment of psoriasis and multiple sclerosis
Dimethyl fumarate (DMF) is a methyl ester of fumaric acid and has recently gained attention due to its use as a pro-drug in different pharmaceutical preparations, besides the low price of the final
Halloysite-Catalyzed Esterification of Bio-Mass Derived Acids
Halloysite, a natural clay with a hollow tubular structure, was studied as a catalyst for the esterification of biomass-derived carboxylic acids with four different alcohols with high yields of the corresponding esters and diesters.
A Brønsted acidic, ionic liquid containing, heteropolyacid functionalized polysiloxane network as a highly selective catalyst for the esterification of dicarboxylic acids
A Bronsted acidic, ionic liquid containing, heteropolyanion functionalized polysiloxane network was formed by self-condensation of dodecatungstophosphoric acid and a zwitterionic organosilane
Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry.
A combination of simplified and automated systems are discussed, demonstrating how flow chemistry solutions can be tailored to fit the specific needs of a project.