Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.

@article{Wood2002DimersTD,
  title={Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.},
  author={Zachary A Wood and Leslie B. Poole and Roy R. Hantgan and P. Andrew Karplus},
  journal={Biochemistry},
  year={2002},
  volume={41 17},
  pages={5493-504}
}
2-Cys peroxiredoxins (Prxs) are a large and diverse family of peroxidases which, in addition to their antioxidant functions, regulate cell signaling pathways, apoptosis, and differentiation. These enzymes are obligate homodimers (alpha(2)), utilizing a unique intermolecular redox-active disulfide center for the reduction of peroxides, and are known to form two oligomeric states: individual alpha(2) dimers or doughnut-shaped (alpha(2))(5) decamers. Here we characterize both the oligomerization… CONTINUE READING

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References

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Showing 1-5 of 5 references

A yaap, asap, @#*? A set of a Veraging programs, SERC Daresbury Laboratory, Warrington

  • T. A. Jones
  • 1992

inAnalytical ultracentrifugation in biochemistry and polymer science(Harding

  • T. M. Laue, B. D. Shah, T. M. Ridgeway, S. L. Pelletier
  • Eds.) pp
  • 1992

Biochemistry X-ray Crystal Structure of AhpC K

  • R. F. Smith, T. F. Smith
  • Proc. Natl. Acad. Sci. U.S.A
  • 1990
1 Excerpt

Spectroscopy in Biochemistry(Bell

  • C. S. Johnson, D. A. Gabriel
  • J. E., Ed.) pp
  • 1981

inPhysical Biochemistry

  • K. E. Van Holde
  • 1971
1 Excerpt

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