Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.

  title={Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.},
  author={Zachary A Wood and Leslie B. Poole and Roy R. Hantgan and P. Andrew Karplus},
  volume={41 17},
2-Cys peroxiredoxins (Prxs) are a large and diverse family of peroxidases which, in addition to their antioxidant functions, regulate cell signaling pathways, apoptosis, and differentiation. These enzymes are obligate homodimers (alpha(2)), utilizing a unique intermolecular redox-active disulfide center for the reduction of peroxides, and are known to form two oligomeric states: individual alpha(2) dimers or doughnut-shaped (alpha(2))(5) decamers. Here we characterize both the oligomerization… CONTINUE READING


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