Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins.

@article{Carrillo2003DimersOC,
  title={Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins.},
  author={Juan J. Carrillo and John D. Pediani and Graeme Milligan},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 43},
  pages={42578-87}
}
The histamine H1 receptor and the alpha1b-adrenoreceptor are G protein-coupled receptors that elevate intracellular [Ca2+] via activation of Gq/G11. Assessed by co-immunoprecipitation and time-resolved fluorescence resonance energy transfer they both exist as homo-dimers. The addition of the G protein G11alpha to the C terminus of these receptors did not prevent dimerization. Agonists produced a large stimulation of guanosine 5'-3-O-([35S]thio)triphosphate ([35S]GTPgammaS) binding to receptor-G… CONTINUE READING
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