Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'.

@article{Lutters2003DimersOB,
  title={Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'.},
  author={Bianca C H Lutters and R. W. Derksen and Winnie L Tekelenburg and Peter J Lenting and J M M C Arnout and Philip G. de Groot},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 36},
  pages={33831-8}
}
Patients with prolonged clotting times caused by lupus anticoagulant (LAC) are at risk for thrombosis. This paradoxal association is not understood. LAC is frequently caused by anti-beta2-glycoprotein I (beta 2GPI) antibodies. Antibody-induced dimerization of beta 2GPI increases the affinity of beta 2GPI for phospholipids, explaining the observed prolonged clotting times. We constructed dimers of beta 2GPI that mimic effects of beta 2GPI-anti-beta 2GPI antibody complexes, and we studied their… CONTINUE READING

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