Dimerizer-mediated regulation of gene expression in vivo.


Several systems have been developed that allow transcription of a target gene to be chemically controlled, usually by an allosteric modulator of transcription factor activity. An alternative is to use chemical inducers of dimerization, or "dimerizers," to reconstitute active transcription factors from inactive fusion proteins. The most widely used system… (More)
DOI: 10.1101/pdb.prot070144


Cite this paper

@article{Rivera2012DimerizermediatedRO, title={Dimerizer-mediated regulation of gene expression in vivo.}, author={V{\'i}ctor Rivera and Lori Berk and Tim P. Clackson}, journal={Cold Spring Harbor protocols}, year={2012}, volume={2012 7}, pages={815-20} }