Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation

Abstract

The neu proto-oncogene encodes a receptor tyrosine kinase (RTK). The oncogenic allele neu* (p185*) bears a glutamic acid for valine substitution at position 664 within the predicted transmembrane domain. We have used this mutant to explore the role of the transmembrane domain in signal transduction by RTKs. Analysis of a panel of neu* proteins with second… (More)
DOI: 10.1038/sj.onc.1200873

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