Dimerization of the human papillomavirus E7 oncoprotein in vivo.

@article{Clemens1995DimerizationOT,
  title={Dimerization of the human papillomavirus E7 oncoprotein in vivo.},
  author={K E Clemens and Roger Brent and Jeno Gyuris and Karl M{\"u}nger},
  journal={Virology},
  year={1995},
  volume={214 1},
  pages={289-93}
}
We have used a yeast two-hybrid system to show that human papillomavirus E7 proteins can form oligomeric complexes in vivo. The carboxyl-terminal cysteine-rich metal-binding domain is critical for this activity although amino-terminal sequences also contribute to oligomerization. Our experiments also reveal that E7 possesses an intrinsic transcription… CONTINUE READING