Dimerization of the guanine-adenine repeat strands of DNA.

  title={Dimerization of the guanine-adenine repeat strands of DNA.},
  author={M. Vorlickova and Iva Kejnovsk{\'a} and Joseph Kovanda and J. Kypr},
  journal={Nucleic acids research},
  volume={27 2},
Jovin and co-workers have demonstrated that DNA strands containing guanine-adenine repeats generate a parallel-stranded homoduplex. Here we propose that the homoduplex is a dimer of the ordered single strand discovered by Fresco and co-workers at acid pH. The Fresco single strand is shown here to be stabilized in aqueous ethanol where adenine is not protonated. Furthermore, we demonstrate that the strands dimerize at higher salt concentrations without significantly changing their conformation… CONTINUE READING

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