Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule.

@article{Cunningham1991DimerizationOT,
  title={Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule.},
  author={Brian C Cunningham and Mark H. Ultsch and Abraham M de Vos and Michael G. Mulkerrin and Karl R. Clauser and James A. Wells},
  journal={Science},
  year={1991},
  volume={254 5033},
  pages={821-5}
}
Human growth hormone (hGH) forms a 1:2 complex with the extracellular domain of its receptor-binding protein (hGHbp) as studied by crystallization, size exclusion chromatography, calorimetry, and a previously undescribed fluorescence quenching assay. These and other experiments with protein engineered variants of hGH have led to the identification of the binding determinants for two distinct but adjacent sites on hGH for the hGHbp, and the data indicated that there are two overlapping binding… CONTINUE READING
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