Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks.

@article{Itakura2005DimerizationOT,
  title={Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks.},
  author={Eisuke Itakura and Isao Sawada and Akira Matsuura},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 12},
  pages={
          5551-62
        }
}
ATR (ATM and Rad3-related), a PI kinase-related kinase (PIKK), has been implicated in the DNA structure checkpoint in mammalian cells. ATR associates with its partner protein ATRIP to form a functional complex in the nucleus. In this study, we investigated the role of the ATRIP coiled-coil domain in ATR-mediated processes. The coiled-coil domain of human ATRIP contributes to self-dimerization in vivo, which is important for the stable translocation of the ATR-ATRIP complex to nuclear foci that… CONTINUE READING
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