Dimerization of the 3'UTR of bicoid mRNA involves a two-step mechanism.

  title={Dimerization of the 3'UTR of bicoid mRNA involves a two-step mechanism.},
  author={C{\'e}line Wagner and I Palacios and Luc Jaeger and Daniel St Johnston and Bernard Ehresmann and Chantal Ehresmann and C. Brunel},
  journal={Journal of molecular biology},
  volume={313 3},
The proper localization of bicoid (bcd) mRNA requires cis-acting signals within its 3' untranslated region (UTR) and trans-acting factors such as Staufen. Dimerization of bcd mRNA through intermolecular base-pairing between two complementary loops of domain III of the 3'UTR was proposed to be important for particle formation in the embryo. The participation in the dimerization process of each domain building the 3'UTR was evaluated by thermodynamic and kinetic analysis of various mutated and… CONTINUE READING

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