Dimerization of p15RS mediated by a leucine zipper–like motif is critical for its inhibitory role on Wnt signaling

  title={Dimerization of p15RS mediated by a leucine zipper–like motif is critical for its inhibitory role on Wnt signaling},
  author={Xuanzi Fan and Juan Zhao and F. Ren and Yinyin Wang and Yarui Feng and Lidan Ding and Linpeng Zhao and Y. Shang and J. Li and J. Ni and B. Jia and Yule Liu and Z. Chang},
  journal={The Journal of Biological Chemistry},
  pages={7618 - 7628}
  • Xuanzi Fan, Juan Zhao, +10 authors Z. Chang
  • Published 2018
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
We previously demonstrated that p15RS, a newly discovered tumor suppressor, inhibits Wnt/β-catenin signaling by interrupting the formation of β-catenin·TCF4 complex. However, it remains unclear how p15RS helps exert such an inhibitory effect on Wnt signaling based on its molecular structure. In this study, we reported that dimerization of p15RS is required for its inhibition on the transcription regulation of Wnt-targeted genes. We found that p15RS forms a dimer through a highly conserved… Expand
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