Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation.

@article{Oppikofer2013DimerizationOS,
  title={Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation.},
  author={Mariano Oppikofer and Stephanie Kueng and Jeremy J. Keusch and Markus Hassler and Andreas G Ladurner and Heinz Gut and Susan M. Gasser},
  journal={The EMBO journal},
  year={2013},
  volume={32 3},
  pages={437-49}
}
Gene silencing in budding yeast relies on the binding of the Silent Information Regulator (Sir) complex to chromatin, which is mediated by extensive interactions between the Sir proteins and nucleosomes. Sir3, a divergent member of the AAA+ ATPase-like family, contacts both the histone H4 tail and the nucleosome core. Here, we present the structure and function of the conserved C-terminal domain of Sir3, comprising 138 amino acids. This module adopts a variant winged helix-turn-helix (wH… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 75 references

Dali server: conservation mapping in 3D

Nucleic acids research • 2010
View 5 Excerpts
Highly Influenced

Transcriptional silencing functions of the yeast protein Orc1/Sir3 subfunctionalized after gene duplication.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 4 Excerpts
Highly Influenced

Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain.

Molecular and cellular biology • 2006
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…