Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC

@inproceedings{Batchelor2011DimerizationOP,
  title={Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC},
  author={Joseph D. Batchelor and Jacob A. Zahm and Niraj H Tolia},
  booktitle={Nature Structural &Molecular Biology},
  year={2011}
}
Plasmodium vivax and Plasmodium knowlesi invasion depends on the parasite Duffy-binding protein DBL domain (RII-PvDBP or RII-PkDBP) engaging the Duffy antigen receptor for chemokines (DARC) on red blood cells. Inhibition of this key interaction provides an excellent opportunity for parasite control. There are competing models for whether Plasmodium ligands engage receptors as monomers or dimers, a question whose resolution has profound implications for parasite biology and control. We report… CONTINUE READING
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