Dimerization of G-protein-coupled receptors.

  title={Dimerization of G-protein-coupled receptors.},
  author={Mark Dean and Christopher Higgs and Richard E. Smith and Robert P. Bywater and Christopher R. Snell and Paul D. Scott and Graham J. G. Upton and Trevor J. Howe and Christopher A. Reynolds},
  journal={Journal of medicinal chemistry},
  volume={44 26},
The evolutionary trace (ET) method, a data mining approach for determining significant levels of amino acid conservation, has been applied to over 700 aligned G-protein-coupled receptor (GPCR) sequences. The method predicted the occurrence of functionally important clusters of residues on the external faces of helices 5 and 6 for each family or subfamily of receptors; similar clusters were observed on helices 2 and 3. The probability that these clusters are not random was determined using Monte… CONTINUE READING

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