Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions.

@article{Wang2006DimerizationOC,
  title={Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions.},
  author={Jinhai Wang and Liusheng He and Christian A. Combs and Gregory Roderiquez and Michael A. Norcross},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 10},
  pages={2474-83}
}
Chemokine receptor CXCR4 (CD184) may play a role in cancer metastasis and is known to form homodimers. However, it is not clear how transmembrane regions (TM) of CXCR4 and receptor homotypic interactions affect the function of CXCR4 in living cells. Using confocal microscopy and flow cytometric analysis, we showed that high levels of CXCR4 are present in… CONTINUE READING