Dimerization and Domain Swapping in G-Protein-Coupled Receptors: A Computational Study

@article{Gouldson2000DimerizationAD,
  title={Dimerization and Domain Swapping in G-Protein-Coupled Receptors: A Computational Study},
  author={Paul R. Gouldson and Christopher Higgs and Richard E. Smith and M. Kristen Dean and Georgios V. Gkoutos and Christopher A. Reynolds},
  journal={Neuropsychopharmacology},
  year={2000},
  volume={23},
  pages={S60-S77}
}
In recent years there has been an increasing number of reports describing G protein-coupled receptor (GPCR) dimerization and heterodimerization. However, the evidence on the nature of the dimers and their role in GPCR activation is inconclusive. Consequently, we present here a review of our computational studies on G protein-coupled receptor dimerization and domain swapping. The studies described include molecular dynamics simulations on receptor monomers and dimers in the absence of ligand, in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 60 CITATIONS, ESTIMATED 60% COVERAGE

A boolean network modelling of receptor mosaics relevance of topology and cooperativity

  • Journal of Neural Transmission
  • 2006
VIEW 6 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Domain swapping in the human histamine H1 receptor.

  • The Journal of pharmacology and experimental therapeutics
  • 2004
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

On the Molecular Basis of the Receptor Mosaic Hypothesis of the Engram

Luigi F. Agnati, Sergi Ferré, +4 authors Kjell Fuxe
  • Cellular and Molecular Neurobiology
  • 2004
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Role of Sulfhydryl Groups in Functioning of Adenylyl Cyclase Signaling System

  • Journal of Evolutionary Biochemistry and Physiology
  • 2002
VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2001
2018

CITATION STATISTICS

  • 6 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 121 REFERENCES

Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers.

  • The Journal of biological chemistry
  • 2000
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Identification and molecular characterization of m3 muscarinic receptor dimers.

  • The Journal of biological chemistry
  • 1999
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL