Dimeric form of diphtheria toxin: purification and characterization.

  title={Dimeric form of diphtheria toxin: purification and characterization.},
  author={Stephen F. Carroll and Joseph T. Barbieri and Robert J. Collier},
  volume={25 9},
Many preparations of diphtheria toxin were found to contain dimeric and multimeric toxin forms. The monomeric and dimeric forms were fractionated to greater than 98% purity, and their properties were compared. Dimeric toxin slowly dissociated to native monomers in solution at neutral pH and could be rapidly dissociated with dimethyl sulfoxide. In cell culture assays and rabbit skin tests, the dimer exhibited no significant toxic activity, except for that attributable to trace contamination by… CONTINUE READING

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