Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions.

@article{Moroz2005DimericDH,
  title={Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions.},
  author={Olga V. Moroz and Alexey G. Murzin and Kira S. Makarova and Eugene V. Koonin and Keith S Wilson and Michael Y. Galperin},
  journal={Journal of molecular biology},
  year={2005},
  volume={347 2},
  pages={243-55}
}
Structure-guided analysis of the new dimeric dUTPase family revealed its sequence relationship to the phage T4 dCTPase, phosphoribosyl-ATP pyrophosphatase HisE, NTP pyrophosphatase MazG, and several uncharacterized protein families, including the human protein XTP3TPA (RS21-C6), which is overexpressed in embryonic and cancer cells. Comparison with the recently determined structure of a MazG-like protein from Sulfolobus solfataricus supported the unification of these enzymes in one superfamily… CONTINUE READING