Dimeric acylphloroglucinols from Hypericum austrobrasiliense exhibiting antinociceptive activity in mice.

Abstract

Three dimeric acylphloroglucinols, austrobrasilol A, austrobrasilol B and isoaustrobrasilol B were isolated from the flowers of Hypericum austrobrasiliense (Hypericaceae, section Trigynobrathys). Their structures were elucidated using mass spectrometry and NMR experiments (1D and 2D), and by comparison with previously reported data for other dimeric acylphloroglucinols isolated from Hypericum and Elaphoglossum genera. The three compounds were orally administered in mice at equimolar doses to uliginosin B (15mg/kg, p.o.) displaying antinociceptive activity in the hot-plate test. The compounds did not induce motor impairment in the rotarod apparatus.

DOI: 10.1016/j.phytochem.2015.12.012

Cite this paper

@article{Bridi2016DimericAF, title={Dimeric acylphloroglucinols from Hypericum austrobrasiliense exhibiting antinociceptive activity in mice.}, author={Henrique Bridi and Gari Vidal Ccana-Ccapatinta and Eveline Dischkaln Stolz and Gabriela de Carvalho Meirelles and S{\'e}rgio Augusto de Loreto Bordignon and Stela M K Rates and Gilsane Lino von Poser}, journal={Phytochemistry}, year={2016}, volume={122}, pages={178-183} }