Dimeric Sfh3 has structural changes in its binding pocket that are associated with a dimer-monomer state transformation induced by substrate binding.

@article{Yuan2013DimericSH,
  title={Dimeric Sfh3 has structural changes in its binding pocket that are associated with a dimer-monomer state transformation induced by substrate binding.},
  author={Ye Yuan and Wei Zhao and Xiao Wang and Yongxiang Gao and Liwen Niu and Maikun Teng},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2013},
  volume={69 Pt 3},
  pages={313-23}
}
Phosphorylated derivatives of phosphatidylinositol (PtdIns), also called phosphoinositides (PIPs), are basic components of membrane-associated signalling systems. A family of PtdIns-transfer proteins (PITPs) called the Sec14 family have been predicted to form a set of functional modules that can sense different types of lipid metabolism and transmit the information to the PIP signalling system. In eukaryotic cells, the Sec14 family exhibits a wide diversity of activity, but the structural basis… CONTINUE READING

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