Dimer formation and transcription activation in the sporulation response regulator Spo0A.

@article{Lewis2002DimerFA,
  title={Dimer formation and transcription activation in the sporulation response regulator Spo0A.},
  author={Richard J Lewis and David J. Scott and James A Brannigan and Joanne C Ladds and Marguerite A. Cervin and George B. Spiegelman and James G Hoggett and Imrich Bar{\'a}k and Anthony James Wilkinson},
  journal={Journal of molecular biology},
  year={2002},
  volume={316 2},
  pages={235-45}
}
The response regulator Spo0A is the master control element in the initiation of sporulation in Bacillus subtilis. Like many other multi-domain response regulators, the latent activity of the effector, C-terminal domain is stimulated by phosphorylation on a conserved aspartic acid residue in the regulatory, N-terminal domain. If a threshold concentration of phosphorylated Spo0A is achieved, the transcription of genes required for sporulation is activated, whereas the genes encoding stationary… CONTINUE READING