Dimensional versus nosographic approach to Alzheimer's disease: therapeutic implications.

@article{Derouesn1990DimensionalVN,
  title={Dimensional versus nosographic approach to Alzheimer's disease: therapeutic implications.},
  author={Christian Derouesn{\'e} and Roland Jouvent},
  journal={Neuroepidemiology},
  year={1990},
  volume={9 4},
  pages={177-82}
}
Negative results in therapeutic trials in Alzheimer's disease (AD) usually account for the nonefficacy of the presently tested drugs. However, methodological flaws in the design of these studies, related to the commonly used nosographic approach, can also be implicated in the lack of demonstration of beneficial results. With regard to the heterogeneity of… CONTINUE READING