Dimenhydrinate Abuse among Adolescentsa

  title={Dimenhydrinate Abuse among Adolescentsa},
  author={David M Gardner and Stan Kutcher},
  journal={The Canadian Journal of Psychiatry},
  pages={113 - 116}
Dimenhydrinate may be a relatively common yet unrecognized substance of abuse among adolescents. Abuse of this drug may present as a psychiatric syndrome, particularly depression. Three cases are presented which illustrate this relationship. A review of the literature is presented and suggestions are made for identifying adolescents who abuse dimenhydrinate. 
Mechanisms and abuse liability of the anti-histamine dimenhydrinate
Anxiety Psychopathology and Alcohol Use among Adolescents: A Critical Review of the Empirical Literature and Recommendations for Future Research
A detailed summary and analysis of the empirical literature focused on specific forms of anxiety psychopathology as they relate to alcohol use among adolescents is presented, and a number of specific recommendations for future work are provided with an emphasis on the utility of experimental psychopathology techniques.
Abuse liability and stimulant properties of dextromethorphan and diphenhydramine combinations in rats
Results show that combinations of DEX and DIP have stimulant properties and are self-administered by animals, an effect that was significantly enhanced when DIP was given in combination with DEX.
Development of a community pharmacy-based model to identify and treat OTC drug abuse/misuse: a pilot study
This study represents the first reportedstructured attempt by community pharmacists in the UK to address the abuse/misuse of OTC medication.
Dimenhydrinate produces a conditioned place preference in rats
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Using the elevated plus-maze, benzodiazepines alleviated cocaine-induced anxiety, while future research on the ability of serotonergic and antihistaminergic drugs to alleviate these anxiety states is warranted.
Development of Weiner et al. Force Field Parameters Suitable for Conformational Studies of [1, 4]-Benzodiazepines and Related Compounds
Molecular mechanics and dynamic simulations showed that AM1 derived parameters, together with MNDO ESP fitted atomic charges, predicted the X-ray structure of a number of representative [1,4]-benzodiazepines within 0.01 A, 0.8 degree, and 5 degrees, from observed bond lengths, bond angles, and bond torsions, respectively.


Dimenhydrinate (Dramamine) abuse: hallucinogenic experiences with a proprietary antihistamine.
The authors conclude that dosage may be a critical factor related to toxic side effects; they also discuss treatment of toxic reactions to the antihistamines.
Diphenhydramine Abuse and Withdrawal-Reply
In view of the features common to withdrawal from many sedating drugs, it is difficult to ascribe the patient's irritability and insomnia specifically to rebound from the anticholinergic and not the sedative effects of diphenhydramine.
Benylin dependence, metabolic acidosis and hyperglycaemia.
A patient who had consumed large quantities of a proprietary cough mixture containing diphenhydramine, ammonium chloride and sodium citrate daily for several months and subsequently presented with confusion, marked metabolic acidosis and non-ketotic hyperglycaemia is described.
Delirium from misuse of dimenhydrinate.
It was found that there is no developmental or degenerative change or combination of such changes which has predictive value when applied to the individual, and the hypothesis that pre-employment radiographic examination provides information which permits identification of individuals who are likely to develop symptoms of lumbar pain under the stress of physical labour is invalid.
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