Dilutional acidosis following hetastarch or albumin in healthy volunteers.

@article{Waters2000DilutionalAF,
  title={Dilutional acidosis following hetastarch or albumin in healthy volunteers.},
  author={Jonathan H Waters and Clifford A Bernstein},
  journal={Anesthesiology},
  year={2000},
  volume={93 5},
  pages={1184-7}
}
BACKGROUND The intent of this study was to evaluate the impact of the commonly used colloids-hetastarch and albumin-on in vivo acid-base balance. From this evaluation, a better understanding of the mechanism of dilutional acidosis was expected. METHODS In a prospective, randomized fashion, 11 healthy volunteers were administered 15 ml/kg hetastarch solution, 6%, or 15 ml/kg albumin, 5%, intravenously over 30 min. Four weeks later, the study subjects were administered the other colloid… CONTINUE READING

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