Dilute Concentrations of a Psychiatric Drug Alter Behavior of Fish from Natural Populations

@article{Brodin2013DiluteCO,
  title={Dilute Concentrations of a Psychiatric Drug Alter Behavior of Fish from Natural Populations},
  author={Tomas Brodin and Jerker Fick and Micael Jonsson and Jonatan Klaminder},
  journal={Science},
  year={2013},
  volume={339},
  pages={814 - 815}
}
Unintended Recipients of Antidepressants Pharmaceuticals are used to treat a wide variety of ailments and conditions in humans. However, many animal species share physiologies, receptors, and pathways that may be acted upon by pharmaceutical compounds. Increasingly, pharmaceuticals are being found in natural aquatic systems. Such pharmaceutical pollution can cause mortality and alter development and reproduction of aquatic animals. Brodin et al. (p. 814) report that excreted drugs may also have… 
An assessment of the risks posed by human pharmaceuticals in the environment to wild birds
TLDR
The observed changes to behaviour and physiology in starlings may have been caused by neuro-adaptations occurring over time, as are observed in humans possibly due to greater receptor sensitivity than humans.
Behavioural and physiological responses of birds to environmentally relevant concentrations of an antidepressant
TLDR
The data suggest that fluoxetine at environmentally relevant concentrations can significantly alter behaviour and physiology in birds, as is optimal for wintering birds.
Environmental relevant levels of a benzodiazepine (oxazepam) alters important behavioral traits in a common planktivorous fish, (Rutilus rutilus)
TLDR
The results reinforce the notion that anxiolytic drugs may be affecting fish behavior in natural systems, emphasizing the need for further research on ecological impacts of pharmaceuticals in aquatic systems and development of new tools to incorporate ecologically relevant behavioral endpoints into ecotoxicological risk assessment.
Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations
TLDR
It is demonstrated that prey consumption can be an important exposure route as on average 46% of the pharmaceutical in ingested prey accumulated in the predator, suggesting that investigations of exposure through bioconcentration, where trophic interactions and subsequent bioaccumulation of exposed individuals are ignored, underestimate exposure.
Environmentally relevant concentrations of tramadol and citalopram alter behaviour of an aquatic invertebrate.
TLDR
The aim of this study was to behaviourally assess the effects of an opioid painkiller and antidepressant drug on behaviour patterns of a clonal model species, marbled crayfish.
Concentrating mixtures of neuroactive pharmaceuticals and altered neurotransmitter levels in the brain of fish exposed to a wastewater effluent.
TLDR
Investigation of the uptake of 14 neuroactive pharmaceuticals from a treated wastewater effluent into blood plasma and brain regions of roach after exposure for 15days indicated that fluoxetine, norfluoxettine, sertraline, and amitriptyline warrant prioritisation for risk assessment studies.
Short-term effects of neuroactive pharmaceutical drugs on a fish species: biochemical and behavioural effects.
TLDR
The results enlighten the need for more research on the ecological consequences of pharmaceuticals in the aquatic environment, especially drugs that interfere with the CNS and behaviour, because the net outcome of these effects may be difficult to predict.
Ecological implications of altered fish foraging after exposure to an antidepressant pharmaceutical.
TLDR
Feed trials using juvenile Eurasian perch exposed to the selective serotonin reuptake inhibitor (SSRI) sertraline are performed to test the hypothesis that sERTraline alters foraging ecology of the fish in terms of their functional response, and found an exposure-dependent decrease in feeding with increasing sertrals.
Low concentrations of the benzodiazepine drug oxazepam induce anxiolytic effects in wild-caught but not in laboratory zebrafish.
TLDR
While wild-caught zebrafish exposed to concentrations of the anxiolytic drug oxazepam as low as 0.57 μg L-1 showed a reduction in the response to conspecific alarm pheromone, laboratory strain AB did not respond to the alarm cue, and consequently, the anxIOlytic effect of oxzepam could not be measured.
Home alone-The effects of isolation on uptake of a pharmaceutical contaminant in a social fish.
TLDR
It is found that single exposed individuals to take up more oxazepam than individuals exposed in groups, likely as a result of stress caused by isolation, and the bioconcentration factor was significantly negatively correlated with fish weight in both social treatments.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
Psychiatric pharmaceuticals in the environment.
TLDR
The literature data related to the occurrence, persistence, environmental fate and toxicity for non-target organisms of this group of pharmaceuticals are reviewed and the analytical methods developed for the determination of psychiatric medicines in environmental matrices are highlighted.
Evolutionary conservation of human drug targets in organisms used for environmental risk assessments.
TLDR
It is proposed that aquatic environmental risk assessments for human drugs should always include comprehensive studies on aquatic vertebrates, and individual targets, especially enzymes, are well conserved suggesting that tests on evolutionarily distant organisms would be highly relevant for certain drugs.
Photodegradation of psychiatric pharmaceuticals in aquatic environments--kinetics and photodegradation products.
TLDR
The results highlight that photodegradation might not be an efficient pathway to prevent the aquatic environmental accumulation of oxazepam, diazepam and alprazolam.
Environmental occurrence, fate and transformation of benzodiazepines in water treatment.
TLDR
Results reveal the recalcitrant nature of benzodiazepine derivatives and suggest that only combinational treatment is sufficient to remove them, and eight novel diazepam and four novel oxazepam transformation products are reported.
Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass Spectrometry.
TLDR
A multi-residue method was developed that allows for the simultaneous determination of psychoactive compounds such as opioids, tranquilizers, antiepileptics and the cocaine metabolite benzoylecgonine, as well as the calcium channel blocker verapamil in raw and treated wastewater, surface water, groundwater, and drinking water.
Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment--a review.
TLDR
This analysis shows that the highest amounts discharged through secondary effluent pertain to one antihypertensive, and several beta-blockers and analgesics/anti-inflammatories, while the highest risk is posed by antibiotics and several psychiatric drugs and analgesic/ anti- inflammatories.
Plasticity of boldness in rainbow trout, Oncorhynchus mykiss: do hunger and predation influence risk-taking behaviour?
TLDR
A divergence in the ability of bold and shy trout to alter their behavioural profiles in response to internal and exogenous factors is suggested, which has important implications for the understanding of the maintenance of different behavioural phenotypes in natural populations.
Behavioral syndromes: an ecological and evolutionary overview.
TLDR
The existence of behavioral syndromes focuses the attention of behavioral ecologists on limited (less than optimal) behavioral plasticity and behavioral carryovers across situations, rather than on optimal plasticity in each isolated situation.
The Energetics of Feeding, Metabolism and Growth of Brown Trout (Salmo trutta L.) in Relation to Body Weight, Water Temperature and Ration Size
TLDR
The chief purpose of the present paper is to provide information on feeding and growth in brown trout and to develop equations to estimate the various components of the energy budget.
Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions?
TLDR
This exercise prioritized the most critical questions regarding the effects of PPCPs on human and ecological health in order to ensure that future resources will be focused on the most important areas.
...
1
2
3
4
...