Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy.

@article{Higgins1999DiltiazemRR,
  title={Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy.},
  author={Rosemary D. Higgins and Kim Yu and Rebecca J Sanders and Bharat N Nandgaonkar and Tomas Rotschild and Daniel B. Rifkin},
  journal={Current eye research},
  year={1999},
  volume={18 1},
  pages={20-7}
}
PURPOSE To assess the effect of diltiazem, a calcium channel blocking agent, on oxygen induced retinopathy (OIR) in a mouse model using neovascular nuclei quantitation and a quantitative scoring system based on examining fluorescein perfused retinal whole mount preparations. METHODS The mouse model of oxygen induced retinopathy consisting of a 5 day exposure to 75% oxygen from postnatal day 7 to 12 was used to produce retinal neovascularization. Fluorescein conjugated dextran angiography of… CONTINUE READING
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