Diltiazem increases blood concentrations of cyclized cyclosporine metabolites resulting in different cyclosporine metabolite patterns in stable male and female renal allograft recipients.

@article{Bleck1996DiltiazemIB,
  title={Diltiazem increases blood concentrations of cyclized cyclosporine metabolites resulting in different cyclosporine metabolite patterns in stable male and female renal allograft recipients.},
  author={J{\"o}rg S. Bleck and C. Thiesemann and Volker Kliem and Uwe Christians and Hartmut Hecker and Holger Repp and Ulrich A Frei and Mechthild Westhoff-Bleck and Markus Manns and K. F. Sewing},
  journal={British journal of clinical pharmacology},
  year={1996},
  volume={41 6},
  pages={551-6}
}
1. Six male and six female stable renal allograft recipients under cyclosporine immunosuppression and without concomitant therapy with drugs known either to induce or inhibit CYP3A enzymes were included in the study and received 180 mg day-1 diltiazem for 1 week in a two-period cross-over fashion. Cyclosporine (352 +/- 56 mg day-1) was given in two daily oral doses. The daily doses were not changed during the study. Blood samples were collected for 12 h after receiving cyclosporine alone and… CONTINUE READING

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