Dilazep, an antiplatelet agent, inhibits tissue factor expression in endothelial cells and monocytes.

@article{Deguchi1997DilazepAA,
  title={Dilazep, an antiplatelet agent, inhibits tissue factor expression in endothelial cells and monocytes.},
  author={Hiroko Deguchi and Hiroyuki Takeya and Hideo Wada and Esteban C Gabazza and Naomi Hayashi and Hiroko Urano and Koji A. O. Suzuki},
  journal={Blood},
  year={1997},
  volume={90 6},
  pages={2345-56}
}
Dilazep, an antiplatelet agent, is generally used as an antithrombotic drug in clinical practice. Dilazep is also known to exert cytoprotective and antioxidant effects on endothelial cells. However, its effect on the endothelial or monocyte procoagulant activity is unknown. In the current study, the effect of dilazep on the expression of tissue factor (TF) in human umbilical vein endothelial cells (HUVECs) after the stimulation with tumor necrosis factor-alpha (TNF), thrombin, or phorbol 12… CONTINUE READING