Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

@article{Li1995DilatedCA,
  title={Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase},
  author={Yibing Li and Ting-Ting Huang and Elaine J. Carlson and Simon Melov and Philip C. Ursell and Jean L. Olson and Linda J. Noble and Midori Yoshimura and Christophe Berger and Pak H. Chan and Douglas C. Wallace and Charles J. Epstein},
  journal={Nature Genetics},
  year={1995},
  volume={11},
  pages={376-381}
}
The Sod2 gene for Mn–superoxide dismutase (MnSOD), an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation, was inactivated by homologous recombination. Homozygous mutant mice die within the first 10 days of life with a dilated cardiomyopathy, accumulation of lipid in liver and skeletal muscle, and metabolic acidosis. Cytochemical analysis revealed a severe reduction in succinate dehydrogenase… 
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