Dilated cardiomyopathy

@article{Weintraub2017DilatedC,
  title={Dilated cardiomyopathy},
  author={Robert G. Weintraub and Christopher Semsarian and Peter S. Macdonald},
  journal={The Lancet},
  year={2017},
  volume={390},
  pages={400-414}
}
Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal, sarcomere, and nuclear envelope proteins, among others, account for up to 35% of cases. Acquired causes include myocarditis and exposure to alcohol, drugs and toxins, and metabolic and endocrine disturbances. The most common presenting symptoms relate to congestive heart failure, but can also include circulatory collapse… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy.
TLDR
The myocardial phosphocreatine-to-ATP ratio, measured noninvasively with 31P-MR spectroscopy, is a predictor of both total and cardiovascular mortality in patients with dilated cardiomyopathy. Expand
Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy.
TLDR
It is demonstrated that myocardial PCr/ATP ratios are reduced at rest in human ischemic and idiopathic dilated cardiomyopathy. Expand
Role of Cardiac Magnetic Resonance in the Evaluation of Dilated Cardiomyopathy: Diagnostic Contribution and Prognostic Significance
TLDR
The present review article will focus on the role of CMR in the evaluation of present condition, analysing respective strengths and limitations in the light of current literature and technological developments. Expand
Contributions of 31P-magnetic resonance spectroscopy to the understanding of dilated heart muscle disease.
TLDR
Myocardial 31P-MR spectroscopy can detect abnormal cardiac high-energy phosphate metabolism in patients with heart failure due to DCM and these abnormalities correlate with clinical and haemodynamic parameters. Expand
31P Magnetic Resonance Spectroscopy in Dilated Cardiomyopathy and Coronary Artery Disease: Altered Cardiac High‐Energy Phosphate Metabolism in Heart Failure
TLDR
Cardiac high-energy phosphate metabolism at rest is normal in LAD stenosis and chronic myocardial infarction in the absence of heart failure, and the CP/ATP ratio has low specificity for the diagnosis of dilated cardiomyopathy. Expand
Epidemiology of Heart Failure
  • V. Roger
  • Medicine
  • Circulation research
  • 2013
TLDR
To prevent hospitalizations, a comprehensive characterization of predictors of readmission in patients with HF is imperative and must integrate the impact of multimorbidity related to coexisting conditions. Expand
ATP flux through creatine kinase in the normal, stressed, and failing human heart.
TLDR
The deficit in ATP supplied by CK in the failing heart is cardiac-specific and potentially of sufficient magnitude, even in the absence of a significant reduction in ATP stores, to contribute to the pathophysiology of human heart failure. Expand
Gender-specific differences in left ventricular remodelling in obesity: insights from cardiovascular magnetic resonance imaging.
TLDR
In the absence of traditional cardiovascular risk factors, obese men show predominantly concentric hypertrophy, whereas obese women exhibit both eccentric and concentrichypertrophy. Expand
Assessment of patient outcome with the Minnesota Living with Heart Failure questionnaire: reliability and validity during a randomized, double-blind, placebo-controlled trial of pimobendan. Pimobendan Multicenter Research Group.
To determine the reliability and validity of a patient outcome questionnaire for chronic heart failure, a randomized, double-blind, placebo-controlled, 3-month trial of pimobendan, an investigationalExpand
Magnetic resonance imaging detects significant sex differences in human myocardial strain
TLDR
The finding of significantly larger circumferential and longitudinal LV strain among normal female volunteers suggests that baseline contractile differences between the sexes may contribute to the well-recognized divergence in cardiovascular disease outcomes. Expand
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