Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas.

@article{Yamabuki2007Dikkopf1AA,
  title={Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas.},
  author={Takumi Yamabuki and Atsushi Takano and Satoshi Hayama and Nobuhisa Ishikawa and Tatsuya Kato and Masaki Miyamoto and Tomoo Ito and Hiroyuki Ito and Yohei Miyagi and Haruhiko Nakayama and Masahiro Fujita and Masao Hosokawa and Eiju Tsuchiya and Nobuoki Kohno and Satoshi Kondo and Yusuke Nakamura and Yataro Daigo},
  journal={Cancer research},
  year={2007},
  volume={67 6},
  pages={2517-25}
}
Gene expression profile analysis of lung and esophageal carcinomas revealed that Dikkopf-1 (DKK1) was highly transactivated in the great majority of lung cancers and esophageal squamous cell carcinomas (ESCC). Immunohistochemical staining using tumor tissue microarrays consisting of 279 archived non-small cell lung cancers (NSCLC) and 280 ESCC specimens showed that a high level of DKK1 expression was associated with poor prognosis of patients with NSCLC as well as ESCC, and multivariate… CONTINUE READING