Dihydroxybenzoic acid isomers differentially dissociate soluble biotinyl-Aβ(1-42) oligomers.

@article{Levine2012DihydroxybenzoicAI,
  title={Dihydroxybenzoic acid isomers differentially dissociate soluble biotinyl-Aβ(1-42) oligomers.},
  author={Harry Levine and Levi Lampe and Lina G Abdelmoti and Corinne Elizabeth Augelli-Szafran},
  journal={Biochemistry},
  year={2012},
  volume={51 1},
  pages={307-15}
}
Polyphenolic compounds including a number of natural products such as resveratrol, curcumin, catechin derivatives, and nordihydroguaiaretic acid have effects on the assembly of Aβ fibrils and oligomers as well as on fibril morphology. Based on a lead structure obtained from a screen of a small molecule diversity library, simple benzoic acid derivatives distinguished by the number and position of hydroxyls on the aromatic ring displayed different abilities to dissociate preformed biotinyl-Aβ(1… CONTINUE READING