Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship.

  title={Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship.},
  author={Jie Bao and Jinfeng Luo and Xiaochu Qin and Xin-ya Xu and Xiao-yong Zhang and Zheng-chao Tu and Shuhua Qi},
  journal={Bioorganic \& medicinal chemistry letters},
  volume={24 11},
Four dihydrothiophene-condensed chromones including two new compounds oxalicumones D-E (1-2) and known oxalicumones A-B (3-4), along with five other known chromones were isolated from a culture broth of the marine gorgonian-associated fungus Penicillium oxalicum SCSGAF 0023. The structures of 1-2 were elucidated by spectroscopic analysis. Eleven derivatives 3a-3i and 4a-4b were obtained from the acylation of 3 and 4, respectively. Compounds 1-4, 3a-3e, 3g-3h, and 4b showed significant… Expand
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Dihydrothiophene-Condensed Chromones from a Marine-Derived Fungus Penicillium oxalicum and Their Structure—Bioactivity Relationship.
Oxalicumones D (I) and E (II) are isolated along with the known oxalicumones A-B and five other known chromones from a culture broth of marine gorgonian-associated fungus Penicillium oxalicum SCSGAFExpand
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