Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship.

@article{Bao2014DihydrothiophenecondensedCF,
  title={Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship.},
  author={Jie Bao and Jinfeng Luo and Xiaochu Qin and Xin-ya Xu and Xiao-yong Zhang and Zheng-chao Tu and Shuhua Qi},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2014},
  volume={24 11},
  pages={
          2433-6
        }
}
Four dihydrothiophene-condensed chromones including two new compounds oxalicumones D-E (1-2) and known oxalicumones A-B (3-4), along with five other known chromones were isolated from a culture broth of the marine gorgonian-associated fungus Penicillium oxalicum SCSGAF 0023. The structures of 1-2 were elucidated by spectroscopic analysis. Eleven derivatives 3a-3i and 4a-4b were obtained from the acylation of 3 and 4, respectively. Compounds 1-4, 3a-3e, 3g-3h, and 4b showed significant… Expand
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Dihydrothiophene-Condensed Chromones from a Marine-Derived Fungus Penicillium oxalicum and Their Structure—Bioactivity Relationship.
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References

SHOWING 1-10 OF 11 REFERENCES
Cytotoxic dihydrothiophene-condensed chromones from the marine-derived fungus Penicillium oxalicum.
TLDR
Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus, PenicilliumOxalicum, and the structure-biological activity relationship of 1 was discussed. Expand
Oxepinochromenones, furochromenone, and their putative precursors from the endolichenic fungus Coniochaeta sp.
Six new polyketides including four oxepinochromenones, conioxepinols A-D (1-4), one furochromenone, coniofurol A (5), and one xanthone, conioxanthone A (6), have been isolated from the crude extractExpand
The structures of some metabolites of Penicillium diversum: α-and β-diversonolic esters
The metabolites of Penicillium diversum include the meroterpenoids austinol (1) and isoaustin (2), together with the known poly-β-ketides lichenxanthone (3), alternariol monomethyl ether (4), and twoExpand
The first naturally occurring thiepinols and thienol from an endolichenic fungus Coniochaeta sp.
Coniothiepinols A (1) and B (2) and coniothienol A (3), the first naturally occurring thiepinols (1 and 2) and thienol (3), have been isolated from the crude extract of an endolichenic fungusExpand
Coniochaetones A and B: New antifungal benzopyranones from the coprophilous fungus Coniochaeta saccardoi
Abstract Two new antifungal cyclopentabenzopyran-4-ones, coniochaetones A ( 1 ) and B ( 2 ), have been isolated from liquid cultures of the coprophilous fungus Coniochaeta saccardoi (JS 223). TheExpand
Bioactive Chromone Derivatives – Structural Diversity
TLDR
The present work aims at reviewing the main reported studies on the cytoprotective and anticancer activities of chromone derivatives, with particular emphasis on the effect of their structural features and conformational behaviour on activity, which is the basis of a tailored design of novel chromone-based antioxidants for chemopreventive and chemotherapeutic purposes. Expand
Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023
Two new polyketides, 6,8,5′6′-tetrahydroxy-3′-methylflavone (1) and paecilin C (2), together with six known analogs secalonic acid D (3), secalonic acid B (4) penicillixanthone A (5), emodin (6),Expand
Total syntheses and structural revision of alpha- and beta-diversonolic esters and total syntheses of diversonol and blennolide C.
TLDR
An expedient synthetic strategy for the construction of the diversonolic architecture is reported, its application to concise total syntheses of all three structures 1–3, and the revision of the originally proposed structures for α- and β-diversonolic esters 1 and 2, to 4 and 5, respectively, through total synthesis. Expand
[Rh2(OCOCF3)4] as an auxiliary chromophore in chiroptical studies on steroidal alcohols
Abstract The circular dichroism (CD) of in situ formed complexes of steroidal substituted secondary and tertiary alcohols with [Rh2(OCOCF3)4] have been investigated. The applicability of theExpand
Physiochemical, Optical and Biological Activity of Chitosan-Chromone Derivative for Biomedical Applications
TLDR
The chitosan-chromone derivative gels may open a new perspective in biomedical applications and have antimicrobial activity against Escherichia coli bacteria. Expand
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