Dihydrotestosterone and the Concept of 5α–Reductase Inhibition in Human Benign Prostatic Hyperplasia

@article{Bartsch2000DihydrotestosteroneAT,
  title={Dihydrotestosterone and the Concept of 5$\alpha$–Reductase Inhibition in Human Benign Prostatic Hyperplasia},
  author={Georg Bartsch and Roger S. Rittmaster and Helmut Klocker},
  journal={European Urology},
  year={2000},
  volume={37},
  pages={367 - 380}
}
Objective:The development of the human benign prostatic hyperplasia clearly requires a combination of testicular androgens and aging. Although the role of androgens as the causative factor for human benign prostatic hyperplasia is debated, they undoubtedly have at least a permissive role. The principal prostatic androgen is dihydrotestosterone (DHT). Although not elevated in human benign prostatic hyperplasia, DHT levels in the prostate remain at a normal level with aging, despite a decrease in… 
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