Dihydrotestosterone and the Concept of 5α–Reductase Inhibition in Human Benign Prostatic Hyperplasia

@article{Bartsch2000DihydrotestosteroneAT,
  title={Dihydrotestosterone and the Concept of 5α–Reductase Inhibition in Human Benign Prostatic Hyperplasia},
  author={G. Bartsch and R. Rittmaster and H. Klocker},
  journal={European Urology},
  year={2000},
  volume={37},
  pages={367 - 380}
}
  • G. Bartsch, R. Rittmaster, H. Klocker
  • Published 2000
  • Medicine
  • European Urology
  • Objective:The development of the human benign prostatic hyperplasia clearly requires a combination of testicular androgens and aging. Although the role of androgens as the causative factor for human benign prostatic hyperplasia is debated, they undoubtedly have at least a permissive role. The principal prostatic androgen is dihydrotestosterone (DHT). Although not elevated in human benign prostatic hyperplasia, DHT levels in the prostate remain at a normal level with aging, despite a decrease in… CONTINUE READING
    129 Citations

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    Benign prostate hypertrophy (BPH) and inflammation are common non-cancerous enlargement of the prostate, which result in urinary interference and incomplete drainage of the bladder… Expand
    ConditionsBPH, BPH With Urinary Obstruction, Nocturia, (+2 more)
    InterventionBiological, Device, Procedure
    5α-reductase activity in the prostate
    • 210
    Hormonal treatment of patients with benign prostatic hyperplasia: Pros and cons
    • 7
    Endocrine control of benign prostatic hyperplasia
    • 44
    Benign prostatic hyperplasia: age-related tissue-remodeling
    • 215

    References

    SHOWING 1-10 OF 135 REFERENCES
    Benign Prostatic Hyperplasia: Pathogenesis and Medical Therapy
    • J. Geller
    • Medicine
    • Journal of the American Geriatrics Society
    • 1991
    • 38
    The effect of finasteride in men with benign prostatic hyperplasia.
    • P. Walsh
    • Medicine
    • The Journal of urology
    • 1993
    • 885
    The effect of finasteride in men with benign prostatic hyperplasia. The Finasteride Study Group.
    • 246
    Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism
    • 573
    • Highly Influential