Dihydrorhodamine 123: a new flow cytometric indicator for respiratory burst activity in neutrophil granulocytes

@article{Rothe1988Dihydrorhodamine1A,
  title={Dihydrorhodamine 123: a new flow cytometric indicator for respiratory burst activity in neutrophil granulocytes},
  author={Gregor Rothe and Alan Oser and G{\"u}nter K Valet},
  journal={Naturwissenschaften},
  year={1988},
  volume={75},
  pages={354-355}
}
Granulocytes phagocytose microorganisms and degrade them inside the phagosome by the action of reactive oxygen metabolites, proteases and antibacterial proteins [1, 2]. The production of superoxide anion by a membrane-bound NADPH-oxidase is central for the intracellular oxidative attack of the ingested material. Failure of superoxide anion production during phagocytosis results in severe infection [3]. Extracellular release of superoxide anion and its dismutation product hydrogen peroxide by… CONTINUE READING
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