Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity.

@article{Cho1989DihydropyrimidinesNC,
  title={Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity.},
  author={Hidetsura Cho and Masakazu Ueda and Kazunari Shima and Atsuko Mizuno and M Hayashimatsu and Yasuo Ohnaka and Yoshio Tak{\'e}uchi and Masaki Hamaguchi and Kazuo Aisaka and Toshihiro Hidaka},
  journal={Journal of medicinal chemistry},
  year={1989},
  volume={32 10},
  pages={2399-406}
}
The novel calcium antagonists 3-N-substituted-3,4-dihydropyrimidines 1 and 9 and 3-N-substituted-dihydro-pyrimidin-2(1H)-ones 8 were regioselectively synthesized in good yields. Compounds 1 [especially 1s [R1 = (CH2)2N(benzyl)(2-naphthylmethyl), R2 = i-Pr, X = 0-NO2] and 1t [R1 = (CH2)2N(benzyl)(3,4-dichlorobenzyl), R2 = i-Pr, X = 0-NO2]] exhibited not only more potent and longer lasting vasodilative action but also a hypotensive activity with slow onset as compared with dihydropyridines… CONTINUE READING