Dihydropyrimidine dehydrogenase circadian rhythm in mouse liver: comparison between enzyme activity and gene expression.

@article{Porsin2003DihydropyrimidineDC,
  title={Dihydropyrimidine dehydrogenase circadian rhythm in mouse liver: comparison between enzyme activity and gene expression.},
  author={Bernard Porsin and J. L. Formento and Elisabeth Filipski and M-C Etienne and Mireille Francoual and Nicole Ren{\'e}e and Nicolas Magn{\'e} and Francis L{\'e}vi and G{\'e}rard Milano},
  journal={European journal of cancer},
  year={2003},
  volume={39 6},
  pages={822-8}
}
Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme of 5-fluorouracil (FU) catabolism. The relevance of the measurement of DPD activity for identifying DPD-deficient patients is lessened by circadian variability in DPD activity. Our purpose was to determine whether or not DPD mRNA is sustained by a circadian rhythm. Synchronised mice (male B6D2F1) were sacrificed at 3, 7, 11, 15, 19 or 23 Hours After Light Onset (HALO; eight mice per time-point). Liver DPD activity was determined… CONTINUE READING

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