Dihydroorotate Dehydrogenase Inhibitors: Quantitative Structure-activity Relationship Analysis

@article{Ren1998DihydroorotateDI,
  title={Dihydroorotate Dehydrogenase Inhibitors: Quantitative Structure-activity Relationship Analysis},
  author={Shijun Ren and Sharon K. Wu and Eric Jung-chi Lien},
  journal={Pharmaceutical Research},
  year={1998},
  volume={15},
  pages={286-295}
}
Purpose. The main purpose of this study is to analyze the quantitative structure-activity relationship of two series of dihydroorotate dehydrogenase inhibitors (leflunomide and quinoline carboxylic acid analogues), and to determine the structural requirements for optimum activity of these analogues. Methods. A new CQSAR program was used in deriving regression equations and calculating the octanol/water partition coefficient and the molar refractivity values. The molecular modeling was performed… CONTINUE READING

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