Dihydrofolate reductase mutations in Plasmodium vivax from Indonesia and therapeutic response to sulfadoxine plus pyrimethamine.

@article{Hastings2004DihydrofolateRM,
  title={Dihydrofolate reductase mutations in Plasmodium vivax from Indonesia and therapeutic response to sulfadoxine plus pyrimethamine.},
  author={Michele D Hastings and Kathryn M Porter and Jason D. Maguire and Ika Susanti and Winni Kania and Michael John Bangs and Carol Hopkins Sibley and John Kevin Baird},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={189 4},
  pages={744-50}
}
BACKGROUND The target enzyme of pyrimethamine is dihydrofolate reductase (DHFR), but little is known about allelic variants of dhfr in Plasmodium vivax populations. Still less is known about associations between specific alleles and the failure of sulfadoxine/pyrimethamine (S/P) to clear the erythrocytic stages of P. vivax in vivo. METHODS We studied P. vivax dhfr mutations in 24 patients who received S/P therapy in Papua or Central Java, Indonesia, and we measured the resistance of the… CONTINUE READING
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