Dihydrofolate reductase gene expression in cultured mouse cells is regulated by transcript stabilization in the nucleus

@inproceedings{Leys1984DihydrofolateRG,
  title={Dihydrofolate reductase gene expression in cultured mouse cells is
regulated by transcript stabilization in the nucleus},
  author={Eugene J. Leys and G. F. Crouse and Rodney E. Kellems},
  booktitle={The Journal of cell biology},
  year={1984}
}
Methotrexate-resistant cells, which contain a 500-fold amplification of dihydrofolate reductase (DHFR) genes, were used as a model system for studying the regulation of DHFR gene expression during growth stimulation. We have shown that a threefold increase in DHFR mRNA levels following growth stimulation results from a corresponding increase in DHFR mRNA… CONTINUE READING