Dihydroergotamine, Ergotamine, Methysergide and Sumatriptan – Basic Science in Relation to Migraine Treatment

@article{Dahlf2012DihydroergotamineEM,
  title={Dihydroergotamine, Ergotamine, Methysergide and Sumatriptan – Basic Science in Relation to Migraine Treatment},
  author={Carl G. H. Dahl{\"o}f and Antoinette Maassen van den Brink},
  journal={Headache: The Journal of Head and Face Pain},
  year={2012},
  volume={52}
}
The 5‐hydroxytryptamine (5‐HT) receptor family mediates the effects of several drugs highly effective in migraine primarily by activating 5‐HT1B, 5‐HT1D, and 5‐HT1F receptors. Ergotamine, dihydroergotamine, and methysergide, as well as the “triptan” sumatriptan, are all agonists for these receptors. The receptor profile and degree of selectivity of these four drugs differ, which is reflected by their side effects that limit their use in the acute and prophylactic treatment of migraine. The… 

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  • P. Tfelt-Hansen
  • Medicine
    Cephalalgia : an international journal of headache
  • 2013
DHE has a slow dissociation from the receptor; and this basic attribute of the drug is the most likely cause of the general relatively slow anti-migraine effect of DHE.
...

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