Dihydrocucurbitacin B inhibits delayed type hypersensitivity reactions by suppressing lymphocyte proliferation.

@article{Escandell2007DihydrocucurbitacinBI,
  title={Dihydrocucurbitacin B inhibits delayed type hypersensitivity reactions by suppressing lymphocyte proliferation.},
  author={Jos{\'e} Miguel Escandell and M. Carmen Recio and Salvador M{\'a}{\~n}ez and Rosa Marfa Giner and Miguel Cerd{\'a}-nicol{\'a}s and Rosario Gil-Benso and J V Rios},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={322 3},
  pages={1261-8}
}
We have studied the effects of dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, on different models of delayed type hypersensitivity (DTH) in mice, as well as on T-lymphocyte proliferation and the mediators involved. In experiments with mice, dihydrocucurbitacin B inhibited the inflammatory reactions induced by oxazolone, dinitrofluorobenzene, and sheep red blood cells, reducing both the edema and cell infiltration. Moreover, the analysis of inflamed tissues showed that… CONTINUE READING

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New insight on the bioactivity of cucurbitacins, in Studies in Natural Products Chemistry: Bioactive Natural Products (Atta-ur-Rahman ed

JL Rı́os, JM Escandell, MC Recio
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