Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo

Abstract

Trichuris trichiura is a human parasitic whipworm infecting around 500 million people globally, damaging the physical growth and educational performance of those infected. Current drug treatment options are limited and lack efficacy against the worm, preventing an eradication programme. It is therefore important to develop new treatments for trichuriasis… (More)
DOI: 10.1371/journal.pntd.0005359

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Cite this paper

@inproceedings{Partridge2017Dihydrobenze14oxazepin23HonesAN, title={Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo}, author={Frederick A. Partridge and Emma A Murphy and Nicky J Willis and Carole J. R. Bataille and Ruth A. Forman and Narinder Heyer-Chauhan and Bruno Marini{\vc} and Daniel J C Sowood and Graham M. Wynne and Kathryn Jane Else and Angela J. Russell and David B Sattelle}, booktitle={PLoS neglected tropical diseases}, year={2017} }