Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo.

@article{Disbrow2005DihydroartemisininIC,
  title={Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo.},
  author={Gary L. Disbrow and Astrid C Baege and Katie A Kierpiec and Hang Yuan and Jos{\'e} A. Centeno and Clare A. Thibodeaux and Dan Hartmann and Richard Schlegel},
  journal={Cancer research},
  year={2005},
  volume={65 23},
  pages={10854-61}
}
Nearly all cervical cancers are etiologically attributable to human papillomavirus (HPV) infection and pharmaceutical treatments targeting HPV-infected cells would be of great medical benefit. Because many neoplastic cells (including cervical cancer cells) overexpress the transferrin receptor to increase their iron uptake, we hypothesized that iron-dependent, antimalarial drugs such as artemisinin might prove useful in treating HPV-infected or transformed cells. We tested three different… CONTINUE READING