Dihydroartemisinin inhibits tumor growth of human osteosarcoma cells by suppressing Wnt/β-catenin signaling.

@article{Liu2013DihydroartemisininIT,
  title={Dihydroartemisinin inhibits tumor growth of human osteosarcoma cells by suppressing Wnt/$\beta$-catenin signaling.},
  author={Yueliang Liu and Wen-juan Wang and Jing Xu and Li Li and Qian Dong and Qiong Shi and Guo-wei Zuo and Lan Zhou and Yaguang Weng and Min Tang and Tongchuan He and Jinyong Luo},
  journal={Oncology reports},
  year={2013},
  volume={30 4},
  pages={
          1723-30
        }
}
Osteosarcoma (OS) is the most common type of bone cancer. Even with early diagnosis and aggressive treatment, the prognosis for OS is poor. In the present study, we investigated the proliferation and invasion inhibitory effect of dihydroartemisinin (DHA) on human OS cells and the possible molecular mechanisms involved. We demonstrated that DHA can inhibit proliferation, decrease migration, reduce invasion and induce apoptosis in human OS cells. Using an in vivo tumor animal model, we confirmed… 
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35 Citations
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35 Citations

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Dihydrotanshinone I inhibits the growth of osteosarcoma through the Wnt/β-catenin signaling pathway
TLDR
Dihydrotanshinone I may inhibit the proliferation, migration, and invasion as well as induce the apoptosis of osteosarcoma cells, possibly through suppressing the Wnt/β-catenin signaling pathway.
Dihydroartemisinin suppresses growth of squamous cell carcinoma A431 cells by targeting the Wnt/&bgr;-catenin pathway
TLDR
DHA inhibits skin cancer A431 cells by suppressing Wnt/&bgr;-catenin signaling and induced cell apoptosis and provides a potential target for squamous cell carcinoma treatment.
Dihydroartemisinin inhibits the tumorigenesis and metastasis of breast cancer via downregulating CIZ1 expression associated with TGF-β1 signaling.
TIKI2 suppresses growth of osteosarcoma by targeting Wnt/β-catenin pathway
TLDR
Evidence is provided that reduced expression of TIKI family protein in osteosarcoma may participate in the progression of osteosARcoma and restoring its expression was able to impair the growth of bone-associated malignancy in vivo.
Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells.
TLDR
DHA effectively inhibited cell growth and induced apoptosis in glioma cells and western blot analysis indicated that DHA-induced apoptosis was accompanied by inactivation of the Raf/MEK/ERK and PI3K/AKT signaling pathways, in addition to the downregulation of anti-apoptotic proteins Mcl-1 and Bcl-2 expression levels.
Bone morphogenetic protein 9 regulates tumor growth of osteosarcoma cells through the Wnt/β-catenin pathway.
TLDR
The results revealed that BMP9 can regulate tumor growth of OS cells through the Wnt/β-catenin pathway, and may be a new therapeutic target in OS.
Depletion of ALX1 causes inhibition of migration and induction of apoptosis in human osteosarcoma
TLDR
Depletion of ALX1 caused a dramatic cell cycle arrest, followed by massive apoptotic cell death, and eventually resulted in a significant decrease in migration and invasion of the osteosarcoma cell line studied.
Overexpression of miR-506 suppressed the prolifera- tion and induced apoptosis in osteosarcoma cells in vitro and inhibited tumor formation in vivo. Overexpression of miR-506 significantly inhibited the luciferase activity of AEG‐1 with a wild-type 3'-untranslated region, providing clear evidence th
  • 2016
Overexpression of miR-506 suppresses proliferation and promotes apoptosis of osteosarcoma cells by targeting astrocyte elevated gene-1
TLDR
Overall, the present data indicated that miR-506 functions as a tumor suppressor by targeting AEG-1 in osteosarcoma via the regulation of the Wnt/β-catenin signaling pathway.
The tumor suppressive role of RASSF1A in osteosarcoma through the Wnt signaling pathway
TLDR
RASSF1A functions as a tumor suppressor in osteosarcoma and exerts anti-cancer roles through regulating Akt/GSK-3-Wnt/β-catenin signaling and downregulated the cyclin D1, c-Myc, and matrix metalloproteinase-7 protein levels.
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