Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway

  title={Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway},
  author={Min Lu and Luhaoran Sun and Jin Zhou and Jing Yang},
  journal={Tumor Biology},
Dihydroartemisinin (DHA), a semisynthetic derivative of artemisinin isolated from the traditional Chinese herb Artemisia annua, has been shown to exhibit antitumor activity in various cancer cells, including colorectal cancer. However, the detailed mechanisms underlying its antitumor activity in colorectal cancer remain to be elucidated. In the present study, we investigated DHA-induced apoptosis in human colorectal cancer HCT-116 cells in vitro. The results showed that DHA treatment… CONTINUE READING


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