Dihydroartemisinin-Piperaquine Versus Chloroquine in the Treatment of Plasmodium vivax Malaria in Thailand: A Randomized Controlled Trial

@inproceedings{Phyo2011DihydroartemisininPiperaquineVC,
  title={Dihydroartemisinin-Piperaquine Versus Chloroquine in the Treatment of Plasmodium vivax Malaria in Thailand: A Randomized Controlled Trial},
  author={Aung Pyae Phyo and Khin Maung Lwin and Ric N Price and Elizabeth A Ashley and Bruce Russell and Kanlaya Sriprawat and Niklas Lindeg{\aa}rdh and Pratap Singhasivanon and Nicholas J White and François H Nosten},
  booktitle={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2011}
}
BACKGROUND Chloroquine (CQ) remains the treatment of choice for Plasmodium vivax malaria. Initially confined to parts of Indonesia and Papua, resistance of P. vivax to CQ seems to be spreading, and alternative treatments are required. METHODS We conducted a randomized controlled study to compare the efficacy and the tolerability of CQ and dihydroartemisinin-piperaquine (DP) in 500 adults and children with acute vivax malaria on the Northwestern border of Thailand. RESULTS Both drugs were… CONTINUE READING