Dihydroartemisinin Enhances Apo2L/TRAIL-Mediated Apoptosis in Pancreatic Cancer Cells via ROS-Mediated Up-Regulation of Death Receptor 5

@inproceedings{Kong2012DihydroartemisininEA,
  title={Dihydroartemisinin Enhances Apo2L/TRAIL-Mediated Apoptosis in Pancreatic Cancer Cells via ROS-Mediated Up-Regulation of Death Receptor 5},
  author={Rui Kong and Guang Jia and Zhuo-xin Cheng and Yong-wei Wang and Ming Mu and Shuang-jia Wang and Shang-ha Pan and Yue Gao and HongChi Jiang and De-Li Dong and Bei Sun},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, has recently shown antitumor activity in various cancer cells. Apo2 ligand or tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is regarded as a promising anticancer agent, but chemoresistance affects its efficacy as a treatment strategy. Apoptosis induced by the combination of DHA and Apo2L/TRAIL has not been well documented, and the mechanisms involved remain unclear. METHODOLOGY/PRINCIPAL… CONTINUE READING
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